Current pharmacotherapy options include cytotoxic chemotherapy, anti-VEGF, and anti-EGFR targeting drugs, but these are limited by toxic side effects, limited responses and ultimately resistance.
Cysteinyl leukotriene (Cys LT) signaling regulates intestinal homeostasis with mounting evidence suggesting that Cys LT signaling also plays a role in the pathogenesis of colorectal cancer.
It’s not something you’d expect from someone whose name and fashion house is always associated with high-class taste.
One section of the Met’s 2012 Prada retrospective was titled “Ugly Chic,” but when has Prada ever really ravaged our sense of decorum, or been truly disgusting and tasteless?
Treatment decision is guided by clinical factors (e.g., co-morbid conditions, performance status) and pathological factors (e.g., KRAS mutation status, microsatellite stability status). doi: 10.1126/scisignal.2004350 Pub Med Abstract | Cross Ref Full Text | Google Scholar Hirohashi, S. Inactivation of the E-cadherin-mediated cell adhesion system in human cancers.
CNG channels have a very complex structure with various subunits and domains that play a critical role in their function.
CNG channels are significant in the function of various sensory pathways including vision and olfaction, as well as in other key cellular functions such as hormone release and chemotaxis.
Before their discovery, it was thought that cyclic nucleotides played a role in phosphorylation.
In 1985, it was discovered that c GMP was able to directly activate the light-dependent response of rod ion channels by studying light-adapted retina of frogs.Targeted therapies include the anti-angiogenic drug bevacizumab (Avastin), a humanized monoclonal antibody that binds directly to vascular endothelial growth factor A (VEGF-A; Ferrara et al., 2004). Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors. doi: 10.1038/nature02488 Pub Med Abstract | Cross Ref Full Text | Google Scholar Hennen, S., Wang, H., Peters, L., Merten, N., Simon, K., Spinrath, A., et al. Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist.